This study investigates the adaptation of the novel Nerve Tape device for expanded use in the management of peripheral nerve gap injuries and in repair zones subjected to joint flexion. While Nerve Tape has demonstrated strong preclinical and clinical performance in primary, tension-free nerve repair, this prospective project extends its application to more complex injury patterns involving tissue loss and mechanical tension. The study evaluates Nerve Tape–assisted strategies for autograft and allograft (PNA) repair, cable grafting, repairs under flexion or distributed tension, and conduit-based bridging. Through integrated biomechanical testing and in vivo validation, the project aims to establish sutureless, efficient, and reproducible alternatives to conventional microsuturing techniques for challenging and high-energy nerve injuries.